How DNA methylation affects gene expression
DNA methylation serves as a pivotal epigenetic mechanism that significantly influences gene regulation by recruiting proteins that facilitate gene repression or by hindering transcription factors from...
View ArticleRedefining 5hmC: more than just a stepping stone in the DNA demethylation...
An important DNA modification is methylation, or the addition of a methyl group to the 5th carbon of cytosine. This forms 5-methylcytosine (5mC), typically associated with repression of gene...
View ArticleHow liquid biopsy is transforming neurodegenerative disease diagnosis
Neurodegenerative diseases pose significant challenges in diagnosis and treatment, affecting millions worldwide. These conditions, including Alzheimer’s disease, cause progressive deterioration of the...
View ArticleWhat is epigenetics? A brief introduction into how & why our genes switch on...
Passed from parents to offspring and containing information that will be used to specify physical and biological characteristics, genes are specific sequences within DNA that are responsible for...
View ArticlecfDNA fragmentomics: the next frontier in genetic testing
Cell-free DNA (cfDNA) has emerged as a groundbreaking tool in genetic testing, offering a non-invasive window into the human genome. This circulating DNA, released by cells into the bloodstream,...
View Articlebiomodal to present new 6-base genome data showing enhanced sensitivity for...
CAMBRIDGE, England. biomodal, an omics-based life sciences technology and analytics company, today announced it will present new data highlighting the utility of duet multiomics solution evoC in the...
View ArticleHow histone modifications impact gene regulation
Histones are fundamental proteins that play a crucial role in the organisation and regulation of DNA within eukaryotic cells. These highly conserved proteins are abundant in lysine and arginine...
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Multiomic 6-base data from cell-free DNA enhances the performance of liquid...
Download this poster Credits Fabio Puddu¹Annelie Johansson¹Aurélie Modat¹Jamie Scotcher¹Riccha Sethi¹Shirong Yu¹ ²Nick Harding¹Mark S. Hill¹Ermira Lleshi¹Casper Lumby¹Jean Teyssandier¹Michael Wilson¹...
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Simultaneous single cell sequencing of genetic and epigenetic bases
Download this poster Credits Aldo Ciau-UitzChenfu ShiIris ValentJack M MonahanJinfeng ChenJulia VivianMinna TaipalePáidí CreedPaula GolderPaula Kokko-GonzalesRafael TavaresShankar...
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Inferring genome organisation and gene regulation from 6-base sequencing data
Download this poster Credits Fabio Puddu¹Annelie Johansson¹Aurélie Modat¹Jamie Scotcher¹Riccha Sethi¹Shirong Yu¹ ²Nick Harding¹Mark S. Hill¹Ermira Lleshi¹Casper Lumby¹Jean Teyssandier¹Michael Wilson¹...
View ArticleHow liquid biopsy utilises genetic biomarkers for early diagnosis
Liquid biopsy has emerged as a groundbreaking technique in the field of cancer diagnostics and personalised medicine. This non-invasive method allows for the detection and analysis of genetic...
View ArticleRead our bioRXiv preprint: 5‑methylcytosine and 5‑hydroxymethylcytosine are...
Early cancer detection has the potential to significantly improve treatment outcomes and survival rates. Our study investigates the roles of 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC)...
View ArticleLiquid biopsy: unveiling methylation biomarkers for early cancer diagnosis
The advent of liquid biopsy has sparked a revolution in cancer detection and monitoring. This non-invasive technique allows for the analysis of cell-free DNA (cfDNA) and other analytes found in bodily...
View ArticleTypes of DNA: a comprehensive overview of DNA structures
Deoxyribonucleic acid, or DNA, is the fundamental building block of life, carrying the genetic instructions for all known living organisms and many viruses. This remarkable molecule, with its...
View ArticleWhat factors determine DNA methylation?
DNA methylation, a fundamental epigenetic process, has a profound influence on gene expression and cellular function. This chemical modification of DNA plays a crucial role in various biological...
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Multiomic 6-base sequencing of cell-free DNA improves liquid biopsy classifiers
Download this poster Credits Robert J Osborne¹Fabio Puddu¹, Annelie Johansson¹Aurélie Modat¹Jamie Scotcher¹Riccha Sethi¹Shirong Yu¹ ²Nick Harding¹Mark Hill¹Ermira Lleshi¹Casper Lumby¹Jean...
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A high-performance toolkit for large-scale analysis of 5- and 6-base genomes
Download this poster Credits Jean TeyssandierNicholas HardingSabri JamalMichael J. WilsonGary FrewinNicola WongWilliam StarkMark S. HillPáidí Creed 1. Introduction We present a computational toolkit...
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OGT prevents DNA demethylation and suppresses the expression of transposable...
Download this poster Credits Robert Crawford¹ Hugo Sepulveda Xiang Li Leo J. Arteaga-Vazquez Isaac F. López-Moyado Melina Brunelli Lot Hernandez Espinosa Xiaojing Yue J. Carlos Angel Caitlin Brown...
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Multiomic 6-base sequencing enhances the performance of early colorectal...
Download this poster Credits Fabio Puddu¹Annelie Johansson¹Aurélie Modat¹Jamie Scotcher¹Riccha Sethi¹Nick Harding¹Mark Hill¹Ermira Lleshi¹Casper Lumby¹Jean Teyssandier¹Michael Wilson¹Robert...
View ArticleThe ‘six-base genome’ sheds light on hidden cancer dynamics
Tracking cancer epigenetics While early liquid biopsy research efforts focused on detecting DNA sequence changes, the importance of epigenetics has recently come to the fore, says Sarah-Jane Dawson, a...
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